abstract：BACKGROUND:Serum levels of Phosphate (P), Calcium (Ca) and Parathyroid hormone (PTH) show circadian rhythms in healthy people. The aim of this study is to investigate whether there is also a rhythm in Hemodialysis (HD) patients. METHODS:We studied 15 (11 M, 4 F) HD patients, ages were 26 - 70 (mean 53 +/- 15) years. T...

journal_title：Clinical laboratory

authors： Micozkadioglu H,Ozelsancak R,Yildiz I,Erken E,Zumrutdal A,Torun D,Haberal M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Arthritis is a chronic inflammatory disease resulting in inflammation of diarthrodial joints (particularly joints of hands, wrists, feet, knees, ankles, and shoulders), manifested by swelling and functional impairment. This study was designed to evaluate the levels of the toxic elements arsenic (As), cadmium...

journal_title：Clinical laboratory

authors： Afridi HI,Kazi TG,Kazi N,Talpur FN,Shah F,Naeemullah,Arain SS,Brahman KD

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The putative association between serum adiponectin levels and colorectal adenomas is actually under debate. The aim of this study was to investigate this association in relation to factors known to influence the levels of adiponectin such as anthropometric, metabolic, inflammatory parameters as well as lifes...

journal_title：Clinical laboratory

authors： Danese E,Minicozzi AM,Montagnana M,De Manzoni G,Lippi G,Guidi GC

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The study was conducted in order to analyze the incidence of heparin-induced thrombocytopenia (HIT) and heparin-induced thrombocytopenia and thrombosis syndrome (HITTS) in 240 patients from the Department of Vascular Surgery in China, to evaluate the current laboratory detection technique, and to explore the...

journal_title：Clinical laboratory

authors： Wang J,Dong X,Xin Y,Xu P,Xue Y,Wang L,Wang Y,Wang C,Chen X,Guan Y,Liu J,Chang Y,Gao X,Jin Y,Zhang Y,Li X,Dai H

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:CA 19-9 is one of the most frequently used biomarkers for tumors. METHODS:We analyzed the influential factors of the Carbohydrate Antigen 19-9 (CA 19-9) levels in Chinese general population to better interpret the results of the CA 19-9 screening tests. 36,924 apparently healthy individuals and 1,335 patien...

journal_title：Clinical laboratory

authors： Wang YZ,Zhou YW,Xie XY,Li GL,Wang XH,Li FY,Le ZA,Zhong YH,Zhang J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The objective of the study was to compare the analytical performance of three automated immunoassays for the determination of serum 25-hydroxyvitamin D. METHODS:Quantitative determination of serum 25(OH)D were performed by "Vitamin D total" (n = 131) and "Vitamin D3(25-OH)" (n = 77) assays (Roche Diagnostic...

journal_title：Clinical laboratory

authors： Martins-Costa P,Martins H,Bravo F,Cruz M,Reis J,Oliveira JC

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the diagnostic performance of the new Sekisui Virotech Treponema pallidum Screen ELISA in comparison with the currently used treponemal tests, TPPA and FTA-abs, and to compare this new ELISA to the FDA approved Phoenix Trep-Sure ELISA. METHODS:To establish the sensi...

journal_title：Clinical laboratory

authors： Busse C,Navid MH,Strubel A,Schnitzler P

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:During pregnancy hormonal changes may increase the risk for developing gingivitis. The aim of this study was to evaluate the signs of gingival inflammation and the enzyme activity of matrix metalloproteinase-8 (aMMP-8) in the gingival crevicular fluid of pregnant women. METHODS:After approval by the ethics ...

journal_title：Clinical laboratory

authors： Ehlers V,Callaway A,Hortig W,Kasaj A,Willershausen B

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Here, we report the first case of patient with intracranial tumors (ICT) who developed a cutaneous adverse drug reaction during lansoprazole and prophylactic anticonvulsant treatment. SCORTEN is a scoring system used to predict mortality in TEN patients. If SCORTEN index is 5 or more, mortality rate is more ...

journal_title：Clinical laboratory

authors： Yalcin AD,Karakas AA,Soykam G,Gorczynski RM,Sezer C,Bisgin A,Strauss LG

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Eps8 is a novel proto-oncogene related to the tumorigenesis, proliferation, metastasis, chemo-resistance, and prognosis of many human solid cancers. However, the function of Eps8 in acute myeloid leukemia (AML) is still unclear. Thus, this study aims to develop a real-time quantitative polymerase chain react...

journal_title：Clinical laboratory

authors： Wang L,Cai SH,Xiong WY,He YJ,Deng L,Li YH

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Low birth weight (LBW) might be a risk factor for acquiring lower respiratory tract infections (LRTIs) associated with disease related complications in early childhood. HFMD, a frequent viral infection in southern China, is a leading cause of lower respiratory tract infections in children. We analyzed whethe...

journal_title：Clinical laboratory

authors： Lu YP,Zeng DY,Chen YP,Liang XJ,Xu JP,Huang SM,Lai ZW,Wen WR,Von Websky K,Hocher B

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Cortactin is an important regulator involved in invasion and migration of tumor cells. Although the relationship between cortactin and tumor invasion has been reported, it lacks follow-up evidence to support the forecasting role of cortactin for HCC prognosis. The aim of this study was to determine whether c...

journal_title：Clinical laboratory

authors： Gang Z,Ya-Lin K,Dong-Qing W,Yu L,Li R,Hong-Yi Z

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Advanced type 2 diabetes mellitus (T2DM) needing insulin therapy is common. Most conventional anti-hyperglycemic drugs have limited efficacies and significant side effects, so that better anti-hyperglycemic agents are needed. Urtica dioica L. (nettle) leaves have insulin secretagogue, PPARgamma agonistic, an...

journal_title：Clinical laboratory

authors： Kianbakht S,Khalighi-Sigaroodi F,Dabaghian FH

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:The spectrum of laboratory tests used to detect monoclonal components (M-components) include serum and urine protein electrophoresis (PEP), immunofixation electrophoresis, and immunonephelometric methods such as free light chain assay (sFLC). METHODS:In this study, we retrospectively analyzed 78 patients wh...

journal_title：Clinical laboratory

authors： Cho SY,Nam YS,Yoon HJ,Lee HJ,Park TS

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Gene therapy may offer a new tool for the treatment of bladder cancer. Previously, we have shown a significant antitumor effect in bladder cancer xenografts in a nude mouse model using intratumoral herpes simplex virus thymidine (HSV-TK) and endostatin gene monotherapy. METHODS:Given the high vascularity of...

journal_title：Clinical laboratory

authors： Pan JG,Luo RQ,Zhou X,Han RF,Zeng GW

更新日期：2013-01-01 00:00:00

abstract：:Alcohol biomarkers play a significant role in the early diagnosis of alcohol intoxication/abuse, alcohol-related organ damages, assessment of alcoholism therapy outcomes, and in forensic medicine. Laboratory detection of excessive alcohol consumption can be carried out by direct measuring of the ethanol and/or metabol...

journal_title：Clinical laboratory

authors： Topic A,Djukic M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Expression of the human telomerase reverse transcriptase (hTERT) gene, which codes for the catalytic subunit of telomerase is considered an important tumor marker used for bladder cancer detection being found in the majority of cancer cells. Scatter Factor (SF) is a secretory protein produced by fibroblasts ...

journal_title：Clinical laboratory

authors： Eissa S,Motawi T,Badr S,Zaghlool A,Maher A

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Although different approaches have been proposed to selectively determine multiple myeloma (MM) cells in a heterogeneous population of bone marrow (BM) cells, studies on plasma cells from primary samples of MM patients are still challenging. This is partially due to difficulties in obtaining a suitable amoun...

journal_title：Clinical laboratory

authors： Rebersek K,Cernelc P,Podgornik H

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Inflammatory activity is one of the factors involved in the physiopathology of anemia in patients with chronic kidney disease (CKD). The majority of studies on anemia, inflammation, and disturbances of iron metabolism have focused on patients in end-stage renal failure and dialysis therapy. However, anemia a...

journal_title：Clinical laboratory

authors： De Lima GA,Mazzali M,Gentil AF,Plotegher L,Grotto HZ

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:To assess the chronic effect of the DPP-4 inhibitor, linagliptin, alone, in combination with exenatide, and during exenatide withdrawal, in diet-induced obese (DIO) rats. METHODS:Female Wistar rats were exposed to a cafeteria diet to induce obesity. Animals were then dosed with vehicle or linagliptin (3 mg/...

journal_title：Clinical laboratory

authors： Vickers SP,Cheetham SC,Birmingham GD,Rowley HL,Headland KR,Dickinson K,Grempler R,Hocher B,Mark M,Klein T

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Given the huge impact of vitamin D deficiency on a broad spectrum of diseases such as rickets, osteoporosis, mineral bone disease-vascular calcification syndrome, infectious diseases, but also several types of cancer and CNS diseases, reliable and simple methods to analyze the vitamin D status are urgently n...

journal_title：Clinical laboratory

authors： Hocher B,Grön HJ,Schumann C,Tsuprykov O,Seifert S,Hitzler WE,Armbruster FP

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Cytokines are considered important factors for the pathogenesis of asthma as they play a key role in the regulation of immune responses. The aim of this study was to investigate the association between this disease and polymorphisms in the -592 region of the IL-10 gene. METHODS:This study was carried out on...

journal_title：Clinical laboratory

authors： Hakimizadeh E,Arababadi MK,Hassanshahi G,Ahmadabadi BN,Hakimi H,Rezaeian M,Salehabadi VA,Yousefidaredor H,Abousaidi H,Kennedy D

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:During platelet storage, alterations of the platelet function, 'platelet storage lesion', can be observed resulting in a reduced platelet viability. The release of soluble CD40 ligand (sCD40L) by platelets reflects different aspects of platelet metabolism and activity. Therefore, we used the sCD40L release t...

journal_title：Clinical laboratory

authors： Wenzel F,Hohlfeld T,Giers G

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Endothelin-1 (ET-1) is a multifunctional peptide, which is implicated in the renal and cardiac physicology as well as in many pathologies of these systems. ET-1's actions take place after the activation of two receptors: ET(A) and ET(B). The expression of these receptors may be modulated during the pathologi...

journal_title：Clinical laboratory

authors： Vignon-Zellweger N,Rahnenführer J,Theuring F,Hocher B

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Thyroid tumor is the most common malignant cancer of endocrinology, with an increasing incidence in the world. In the absence of specific markers of malignancy, it is a real challenge to distinguish benign and malignant thyroid tumors under the microscope. METHODS:The present study aimed to investigate the ...

journal_title：Clinical laboratory

authors： Cui W,Lu X,Zheng S,Ma Y,Liu X,Zhang W

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Cardiac troponins are the most sensitive and specific biochemical markers of myocardial injury and with the new high-sensitivity troponin methods very minor injuries of the heart muscle can be detected. The introduction of high-sensitivity assays has facilitated reference range adjustments and a revised cut-...

journal_title：Clinical laboratory

authors： Hall TS,Hallén J,Agewall S,Atar D,Jensen T

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:In uremic patients, depending on their type, the T-cells produce a range of pro-inflammatory and anti-inflammatory cytokines. The aim of this study was to compare the effects of chronic kidney disease (CKD) and two different therapy methods of dialysis [hemodialysis (HD) and continuous ambulatory peritoneal ...

journal_title：Clinical laboratory

authors： Kir HM,Eraldemir C,Dervisoglu E,Caglayan C,Kalender B

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Blood pyruvate measurement in conjunction with lactic acid is useful for differentiating pyruvate dehydrogenase deficiencies from primary or secondary disorders of mitochondrial electron transport. METHODS:We evaluated the analytical performance of pyruvate measurement by an enzymatic open channel assay on ...

journal_title：Clinical laboratory

authors： Van den Bossche D,Schiettecatte J,Vekens E,De Smet D,Gorus FK,Martens GA

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:It is generally acknowledged that autoimmune diseases are more prevalent in females worldwide. These diseases are caused by interaction of genetic and environmental factors that result in the failure of immune mechanisms responsible for self-tolerance. One of these mechanisms includes regulatory T cells whic...

journal_title：Clinical laboratory

authors： Afshan G,Afzal N,Qureshi S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Asthma is a chronic inflammatory disease and omalizumab is indicated for moderate-to-severe persistent asthma. The results of many studies have shown that oxidative stress is involved in asthma pathogenesis. However, there is no data available to evaluate the alterations in total antioxidant capacity, hydrog...

journal_title：Clinical laboratory

authors： Yalcin AD,Gorczynski RM,Parlak GE,Kargi A,Bisgin A,Sahin E,Kose S,Gumuslu S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Selenium plays a vital role in the immune status of the individual. The prospective observational study was conducted from September 2009 to March 2010. The aim of the present study is to investigate the association between serum selenium levels and pulmonary tuberculosis (PTB) patients with (n = 40) and wit...

journal_title：Clinical laboratory

authors： Ramakrishnan K,Shenbagarathai R,Kavitha K,Thirumalaikolundusubramanian P,Rathinasabapati R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The biological variability of von Willebrand factor and the variability in assays can make diagnosis and subclassification of von Willebrand disease (VWD) difficult. We describe a case series of four patients with a typical history of VWD and prolonged closure time in the platelet function analyser (PFA-100)...

journal_title：Clinical laboratory

authors： Weiss DR,Strasser EF,Ringwald J,Zimmermann R,Eckstein R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Serum fatty acid content mainly reflects dietary fat intake. It is not known whether alterations of serum fatty acid compositions predict type 2 diabetes risk. METHODS:We evaluated fatty acid contents in serum of the 76 normal and 98 diabetic adults taking part in a cross sectional study, using a gas chroma...

journal_title：Clinical laboratory

authors： Korani M,Firoozrai M,Maleki J,Ghahramanpour F,Heidari I,Fallah S,Seifi M

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Lipoprotein-associated phospholipase A2 (LpPLA2) is a lipoprotein-bound enzyme involved in inflammation and atherosclerosis. This cohort study investigates LpPLA2 concentration to predict cardiovascular and total mortality in patients scheduled for coronary angiography. METHODS:LpPLA2 concentration was dete...

journal_title：Clinical laboratory

authors： Kleber ME,Wolfert RL,De Moissl GD,Grammer TB,Dietz S,Winkelmann BR,Boehm BO,März W

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Cancer is a major cause of death throughout the world. Xanthine oxidase (XO) is considered an oxygen derived free radicals producer and paraoxonasel (PON1) is known as a free radicals scavenger. This study was undertaken to determine the activity of PON1 and XO and their concentration along with the lipid pr...

journal_title：Clinical laboratory

authors： Samra ZQ,Pervaiz S,Shaheen S,Dar N,Athar MA

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor (TNF)-alpha plays a significant role in the pathogenesis of several inflammatory conditions. Several studies confirmed high TNF-alpha plasma protein levels in such conditions and highlighted the utility of TNF-alpha as a biomarker for disease progression or response to biological therap...

journal_title：Clinical laboratory

authors： Alaaeddine N,De Montigny C,Sadouk M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Increased platelet reactivity may contribute to the development of coronary artery disease and myocardial infarction. The aim of the present study was to assess platelet adhesiveness in different stages of coronary artery disease using the platelet adhesion assay (PADA). In addition, the acute effect of coro...

journal_title：Clinical laboratory

authors： Walter T,Szabo S,Kazmaier S,Suselbeck T,Nowak G,Borggrefe M,Hoffmeister HM,Dempfle CE

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to compare the level of calcium (Ca), magnesium (Mg), potassium (K), and sodium (Na) in biological samples (serum, blood, urine, and scalp hair) of patients suffering from different types of viral hepatitis (A, B, C, D, and E; n = 521) of both genders, ages ranged between 31-...

journal_title：Clinical laboratory

authors： Afridi HI,Kazi TG,Kazi N,Kandhro GA,Baig JA,Shah AQ,Khan S,Kolachi NF,Wadhwa SK,Shah F

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:A microbiological method for the quantitative analysis of intravascular catheter infections using the BacT/Alert and Bactec blood culture systems is presented. METHODS:The number of bacteria present on an intravascular catheter surface was determined by the time to detection of positivity in a blood culture...

journal_title：Clinical laboratory

authors： Cermak P,Cermakova S,Schwarzerova A,Klementova M,Ulrychova M,Mazurova J

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Sex hormone binding globulin (SHBG) is important for the transport and regulation of distribution of sex steroids. METHODS:The performance of the Architect SHBG automated immunoassay in comparison to radioimmunoassay was evaluated using 62 patient specimens. Furthermore, specimen from 100 healthy individual...

journal_title：Clinical laboratory

authors： Gruson D,Maisin D,Fillee C

更新日期：2011-01-01 00:00:00